The Ultimate Guide to Infant Formula Types in the U.S.
When you make a purchase through retailer links on my site, I may earn commission through affiliate programs.
Whether you’re combo feeding, exclusively formula feeding, or just need a solid Plan B so someone else can take a night shift (hallelujah), finding the right formula can feel overwhelming. The U.S. formula aisle is packed with options—but not all formulas are created equal, and understanding the different types can save you a whole lot of guesswork, gas, and Google rabbit holes.
Here’s a breakdown of the main types of infant formula available in the U.S., what makes them different, and how to know which one might be right for your baby.
🍼 Cow’s Milk-Based Formula
What it is:
The most common type of formula—made with cow’s milk that’s been modified to be more digestible for babies.
Who it’s for:
Most healthy, full-term babies start here.
Brands to know:
Enfamil NeuroPro, Similac 360 Total Care, Bobbie Organic Infant Formula, Kirkland Signature (Costco), Up & Up (Target)
Pros:
Widely available
Typically the most affordable
Nutritionally complete
Watch out for:
Some babies are sensitive to cow’s milk proteins (more on that below).
🤍 Gentle or Partially Hydrolyzed Formulas
What it is:
The proteins are partially broken down (“hydrolyzed”) so they’re easier to digest.
Who it’s for:
Babies with gas, fussiness, mild reflux, or suspected protein sensitivity—but not a true allergy.
Brands to know:
Enfamil Gentlease, Similac Total Comfort, Gerber Good Start GentlePro
Pros:
Easier on tiny tummies
Often helps with gassiness and spit-up
Watch out for:
Still made with cow’s milk proteins—not suitable for babies with cow’s milk protein allergy (CMPA).
💧 Hypoallergenic (Extensively Hydrolyzed) Formulas
What it is:
These formulas take things a step further—breaking proteins down so much that they’re unlikely to trigger an allergic response.
Who it’s for:
Babies with CMPA, severe food allergies, or serious digestive issues—usually used under pediatric guidance.
Brands to know:
Nutramigen, Alimentum, Gerber Extensive HA
Pros:
Designed for babies with true protein allergies
Clinically tested to be hypoallergenic
Watch out for:
Expensive (but often covered by insurance with a doctor’s note)
Stronger smell and taste—some babies take time to adjust
🐐 Goat Milk-Based Formula (Not FDA-Approved, But Growing in Popularity)
What it is:
Formula made from goat’s milk, which contains a different type of protein that some babies tolerate better.
Who it’s for:
Families looking for a gentler alternative to cow’s milk—but not for babies with true dairy allergies.
Brands to know:
Kendamil Goat, Holle Goat (European; available through reputable importers)
Pros:
Naturally easier to digest for some babies
Creamier texture and different fat profile
Watch out for:
Not approved or regulated by the FDA
Always buy from reputable sources if you go this route
🌱 Soy-Based Formula
What it is:
Uses soy protein instead of dairy. Often chosen by families avoiding animal products or for babies with galactosemia (a rare condition).
Who it’s for:
Babies who can’t tolerate dairy—or families with dietary preferences.
Brands to know:
Enfamil ProSobee, Similac Soy Isomil
Pros:
Dairy-free
Often recommended for specific medical conditions
Watch out for:
Not typically the first choice for mild sensitivities
💡 Organic Formula
What it is:
Made with organic milk and ingredients, free from synthetic pesticides, antibiotics, and GMOs.
Who it’s for:
Parents looking for a “cleaner” formula, similar to European options.
Brands to know:
Bobbie, Earth’s Best Organic, Happy Baby Organic, Loulouka (imported)
Pros:
Tighter ingredient standards
No corn syrup or synthetic additives (especially in brands like Bobbie)
Watch out for:
Organic doesn’t always mean better—read the label to check for hidden sweeteners or palm oil
⚖️ Bonus: Ready-to-Feed vs. Powder vs. Liquid Concentrate
Ready-to-feed: Convenient but $$$. Great for the first few weeks or travel.
Powder: Most cost-effective. Requires careful mixing.
Liquid concentrate: Middle ground—rarely used now, but still available.
👶 Choosing What’s Right for Your Baby
There’s no one-size-fits-all answer. Your baby might thrive on the first formula you try—or you may go through a few before finding the right fit. That’s normal.
Signs it may be time to try a different formula:
Frequent, painful gas or excessive fussiness
Blood in stool or persistent vomiting
Rash, eczema, or signs of allergy
Always consult with your pediatrician if you suspect a medical issue or allergy.
🧡 Final Thoughts from a Newborn Care Pro
Formula feeding shouldn’t feel like guesswork. Whether you’re doing full bottles, combo feeding, or just want to make sure your partner can take a night shift (bless them), there is a formula out there that fits your baby’s needs and your family’s values.
Need help picking one? I offer 30-minute consultation calls where I offer all of your newborn and sleep-related questions—because sleep and sanity start with a well-fed baby and a confident parent.